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近20年来,两性霉素 B 一直是大多数真菌感染病的主要治疗药物,而5-氟胞嘧啶则作为第二线药物,用于两性霉素 B 治疗无效或因毒性反应停药的深部真菌病患者。在全身性真菌病中,曲菌病的发病率占第二位。单独用两性霉素 B 或5-氟胞嘧啶治疗曲菌病疗效一般不理想。本文报告曲菌性肺炎1例,经联合用药治疗收到显著疗效,并着重探讨药物的协同作用。病者男性,48岁,严重烟酒嗜好并患有慢性病的衰弱患者。因进行性呼吸困难和咳嗽咳痰住院。半年中体重减轻7.2kg。有间歇性发热、寒战和肌痛。体检和 X 线检查证实为左下叶肺炎。先用 Floxacillin
Amphotericin B has been the primary treatment for most fungal infections in the past 20 years, whereas 5-fluorocytosine acts as a second-line agent for deep mycosis that is ineffective in amphotericin B or discontinued due to toxic effects patient. In systemic fungal disease, the incidence of aspergillosis in second place. The efficacy of amphotericin B or 5-fluorocytosine alone for the treatment of Aspergillosis is generally not satisfactory. In this paper, one case of aspergillosis pneumonia was reported. The combination therapy has received a significant effect and focused on the synergistic effect of the drugs. Male, 48 years old, with serious alcohol abuse and chronic diseases and weak patients. Due to progressive dyspnea and cough and sputum hospitalization. Half-year weight loss 7.2kg. There are intermittent fever, chills and myalgia. Physical examination and X-ray confirmed the left lower lobe pneumonia. First with Floxacillin