论文部分内容阅读
目的 :研究丙氨瑞林对子宫内膜癌直接作用的可能性。方法 :以不同浓度丙氨瑞林 (浓度为 10 - 9～ 10 - 5 mol/ L)与人子宫内膜癌细胞株 HEC-1A(中分化子宫内膜腺癌 )一起进行培养 72 h,观察各浓度下癌细胞的抑制情况。结果 :当丙氨瑞林浓度为10 - 9mol/ L时 ,癌细胞生长即受到抑制 ,抑制率为 3 7.0± 2 6.2 %;随着丙氨瑞林浓度的增大 ,抑制率渐高。结论 :丙氨瑞林在体外对HEC-1A细胞可能有直接抑制作用 ,且呈剂量依赖关系。
Objective: To investigate the possibility of alarelin on the direct effect of endometrial cancer. Methods: Human endometrial carcinoma cell line HEC - 1A (moderately differentiated endometrial adenocarcinoma) was cultured with different concentration of ararelin (concentration of 10 - 9 ~ 10 -5 mol / L) for 72 h. Inhibition of cancer cells at various concentrations. Results: When the concentration of Alarelin was 10 - 9mol / L, the growth of cancer cells was inhibited, the inhibition rate was 3 7.0 ± 2 6.2%. With the increase of the concentration of Alarelin, the inhibitory rate increased. CONCLUSION: Alarelin may have a direct inhibitory effect on HEC-1A cells in vitro in a dose-dependent manner.