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妊娠第10天大鼠单次灌胃24mg/kg azastene全部达到终止妊娠作用,12或6mg╱kg azastene达到部分终止妊娠作用,3mg/kg azastene则对大鼠终止妊娠无显著作用。妊娠第10天和第11天是azastene对大鼠止孕作用的最佳给药时间。孕酮和消炎痛在妊娠大鼠上均能明显阻断12mg/kg azastene对大鼠的终止妊娠作用。灌胃6mg/kg azastene与肌肉注射0.1mg/kg 15-甲基前列腺素F_(2α)合并用药,其止孕效果较单用azastene或15-甲基前列腺素F_(2α)更为满意。
On the tenth day of gestation, rats were given 24mg / kg azastene orally, all of which achieved termination of pregnancy, 12 or 6mg ig kg of azastene achieved partial termination of pregnancy, and 3mg / kg of azastene had no significant effect on termination of pregnancy in rats. Day 10 and day 11 of gestation are the best administration times of azastene for the conception of pregnancy in rats. Progesterone and indomethacin significantly blocked the termination of pregnancy in rats at 12 mg / kg azastene in pregnant rats. Administration of 6 mg / kg azastener and intramuscular injection of 0.1 mg / kg 15-methyl prostaglandin F 2α together were more satisfactory than those of azastene alone or 15-methyl prostaglandin F 2α.