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目的 了解类风湿关节炎（ＲＡ） 滑膜巨噬细胞与病情活动性及关节破坏的相关性以探讨其检测的临床意义。方法 采用ＣＤ６８ 免疫组化ＬＳＡＢ染色法检测了ＲＡ、非ＲＡ及正常滑膜巨噬细胞，并分析ＲＡ 滑膜衬里下层浸润的巨噬细胞数与ＲＡ 病情活动指标及Ｘ 线关节破坏指标之间的关系。结果 ＲＡ 滑膜衬里下层浸润的巨噬细胞数较非ＲＡ 滑膜明显增多，其不仅与关节疼痛数、关节压痛数、ＥＳＲ、ＣＲＰ等ＲＡ 病情活动指标呈明显的正相关，而且还与Ｘ 线关节破坏的侵蚀积分和狭窄积分呈明显的正相关（Ｐ＜ ０－０５ 或Ｐ＜０－０１）。结论 滑膜巨噬细胞的检测有助于ＲＡ 的病情判断（包括病情活动性及关节破坏） 及预后分析。
Objective To investigate the correlation between rheumatoid arthritis (RA) synovial macrophages and disease activity and joint destruction to explore its clinical significance. Methods RA, non-RA and normal synovial macrophages were detected by CD68 immunohistochemical LSAB staining. The number of infiltrating macrophages in RA synovial lining and RA disease activity index and X-ray joint destruction index relationship. Results Compared with non-RA synovial membrane, the number of infiltrating macrophages in RA synovial lining was significantly increased, which was not only positively correlated with the number of joint pain, joint tenderness, ESR, CRP RA activity, but also with the X-ray There was a clear positive correlation between erosion scores and stenosis scores of joint destruction (P <0-05 or P <0-01). Conclusion The detection of synovial macrophages contributes to the judgment of the disease (including disease activity and joint destruction) and prognosis.