论文部分内容阅读
肝脏腺瘤是一种少见的肝脏良性肿瘤,多发生于青年女性。据报道,发病与长期应用口服避孕药密切相关。肝脏腺瘤无特异性的临床表现,诊断主要依靠影像学检查及活检。肝脏腺瘤具有易出血、易恶变的特点,临床上需积极干预处理。近来通过分子生物学技术,将肝脏腺瘤分为特点明显的3个大类:炎性肝脏腺瘤、肝细胞核因子1α变异性肝脏腺瘤和β连环蛋白激活肝脏腺瘤。3个亚类在病理学特征、癌变预后等方面均不相同,为进一步个体化治疗提供了依据。
Liver adenoma is a rare benign liver tumors, mostly in young women. It is reported that the incidence and long-term use of oral contraceptives are closely related. Liver adenoma non-specific clinical manifestations, the diagnosis depends mainly on imaging and biopsy. Hepatic adenoma with easy bleeding, easy to malignant changes in the characteristics of the need for clinical intervention. Recently, through molecular biology techniques, hepatic adenomas have been divided into three distinct groups: inflammatory liver adenoma, hepatic nuclear factor-1alpha variant hepatic adenoma and beta-catenin activating hepatic adenoma. The three subtypes are different in the pathological features and canceration prognosis, which provide the basis for further individualized treatment.