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目的了解慢性乙型肝炎中庚型肝炎病毒（ＨＧＶ）的感染率及其对病变程度和ＨＢＶ复制的影响。方法逆转录聚合酶链反应（ＲＴＰＣＲ）检测６５例经肝活检证实的慢性乙型肝炎患者血清中ＨＧＶＲＮＡ。结果有８例（１２．３％）慢性乙型肝炎患者合并ＨＧＶ感染，轻度、中度和重度患者中的ＨＧＶ检出率统计学处理差异无显著性，ＨＧＶ混合感染与其临床表现无相关性，ＨＧＶ阳性组与阴性组患者的肝功能改变相近。ＨＢｅＡｇ阳性组和ＨＢｅＡｇ阴性组患者的ＨＧＶ检出率亦相当。结论在慢性乙型肝炎患者中，ＨＧＶ混合感染对慢性乙型肝炎的病变程度及病毒复制无明显影响
Objective To understand the infection rate of hepatitis G virus (HGV) in chronic hepatitis B and its influence on the degree of lesion and HBV replication. Methods Reverse transcription polymerase chain reaction (RTPCR) was used to detect serum HGVRNA in 65 patients with chronic hepatitis B confirmed by liver biopsy. Results 8 cases (12.3%) of patients with chronic hepatitis B had HGV infection. There was no significant difference in the detection rate of HGV among mild, moderate and severe cases, but there was no correlation between HGV mixed infection and clinical manifestations , Liver function changes in HGV positive group and negative group were similar. The detection rate of HGV in patients with HBeAg-positive and HBeAg-negative was similar. Conclusion In patients with chronic hepatitis B, the mixed infection of HGV has no significant effect on the degree of disease and virus replication in chronic hepatitis B