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目的探讨宫颈活体组织病理检查与宫颈超薄液基细胞学检查在诊断意义未明的不典型鳞状细胞(ASC-US)中的应用价值。方法对308例用宫颈新柏氏液基细胞学检查(TCT)为ASC-US的患者,同时进行多点活体组织病理学检查和高危型HPV-DNA检测,将结果进行对比研究。结果 308例ASC-US患者中病理学检查,诊断宫颈上皮内瘤变(CIN)127例(41.2%),其中高级别CIN(CINⅡ～CINⅢ)33例(10.7%),炎症181例(59.7%);高危型HPV-DNA检测阳性116例(37.7%),其中CIN 81例(26.3%),高级别CIN 30例(9.7%)。结论对30～49岁年龄段女性宫颈筛查中发现的ASC-US病例和HPV-DNA检测中高危型HPV阳性者应做病理活检。
Objective To investigate the value of cervical biopsy and ultra-thin cervical liquid-based cytology in the diagnosis of atypical squamous cells (ASC-US) with unknown significance. Methods 308 patients with Cervical cytopathy (TCT) were enrolled in ASC-US. Multiple biopsies and high-risk HPV-DNA tests were performed at the same time. The results were compared. Results Thirty-seven patients (41.2%) had cervical intraepithelial neoplasia (CIN) diagnosed by pathological examination in 308 ASC-US patients, including 33 (10.7%) with high grade CIN (CINⅡ- CINⅢ), 181 (59.7% ), And 116 (37.7%) were positive for high-risk HPV-DNA test, of which 81 (26.3%) were CIN and 30 (9.7%) were high-grade CIN. Conclusions Pathological biopsy should be performed on ASC-US cases found in cervical screening of women aged 30-49 years and high-risk HPV-positive in HPV-DNA testing.