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目的 依据伽玛刀治疗垂体腺瘤前、后的MR表现及内分泌变化 ,评价伽玛刀治疗垂体腺瘤的效果。方法 回顾性分析45例在我院行伽玛刀治疗后随访时间为 1～ 2 8个月共 5 9例次的垂体瘤病人的平扫、增强MR资料结合临床资料及内分泌化验检查。分析垂体肿瘤直径的变化 ,强化特征及临床症状、激素水平的变化。结果 肿瘤体积缩小 3 1例 (占 5 2 .5 % ) ,体积不变 2 5例 (占42 .4% ) ,体积增大 3例 (占 5 % )。其中囊变 15例 (占 2 5 % )。功能性腺瘤共获 2 3例随访结果 ,总好转率为 13例 (5 6.5 % ) ,半年好转率 8.6% ,1年 13 % ,2年左右 3 4.8%。结论 伽玛刀治疗垂体腺瘤可较好地控制肿瘤的生长 ,控制功能性腺瘤的过量激素分泌 ,且这种作用随着时间延长具有放大作用。
Objective According to the gamma knife treatment of pituitary adenoma before and after the MR performance and endocrine changes, evaluate the efficacy of gamma knife treatment of pituitary adenoma. Methods The clinical data of 45 cases of pituitary adenoma who underwent gamma knife treatment in our hospital from January to August, with a total of 59 cases were retrospectively analyzed. The clinical data and endocrine tests were compared between the two groups. Analysis of pituitary tumor diameter changes, to strengthen the characteristics and clinical symptoms, hormone levels change. Results Tumor volume was reduced in 31 cases (52.5%), unchanged volume in 25 cases (42.4%) and volume increase in 3 cases (5%). Among them, 15 cases of cystic degeneration (25%). A total of 23 cases of functional adenomas were followed up. The overall improvement rate was 13 cases (6.55%). The half-year improvement rate was 8.6%, 1 year 13% and 2 4.8%. Conclusion Gamma knife treatment of pituitary adenoma can better control the tumor growth, control the secretion of excess hormones of functional adenoma, and this effect with the extension of time with amplification.