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英卡因(encainide)和弗雷卡因(fle-cainide)是两种抗心律失常的新药。研究结果证实,这两种新药具有疗效高、毒性低、治疗剂量范围广的特点。英卡因在化学结构上与普鲁卡因酰胺相类似。药物半衰期为1.9—3.8小时。血浆浓度为10~(-9)/毫升时高效。治疗剂量为每8小时口服25—100mg,持续用药6—12月。该作者对11例用目前常用的抗心律失常药物不能完全控制的顽固快速性心律失常的病人在用本药治疗后,10例疗效显著,室性异位搏动的消除平均达99.6%,1例无效。临床上未发现有严重的副作用。仅有两个病人治疗剂量高达每6小时
Encainide and fle-cainide are two new anti-arrhythmic drugs. The results confirm that these two new drugs have the characteristics of high efficacy, low toxicity and wide therapeutic dose range. Ampicillin is chemically similar to procainamide. The half-life of the drug is 1.9-3.8 hours. Plasma concentration of 10 ~ (-9) / ml when efficient. Therapeutic dose of oral 25-100mg every 8 hours, continuous medication 6-12 months. The authors of 11 patients with the current commonly used anti-arrhythmic drugs can not be completely controlled refractory tachyarrhythmia patients treated with this drug, 10 cases of significant effect, the elimination of ventricular ectopic beat an average of 99.6%, 1 case invalid. Clinically no serious side effects were found. Only two patients treat doses up to every 6 hours