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本文用核酸杂交法对以维吾尔族为主的宫颈癌及非癌宫颈组织进行了HPV-DNA相关序列的检查。标本有宫颈癌33例、宫颈糜烂1例和正常宫颈1例。在33例宫颈癌中维吾尔旅有25例,其余8例包括汉、蒙古、回和柯尔克孜等四个民族。结果是在维吾尔族病例宫颈癌组织中HPV-DNA相关序列检出率达80％,以HPV_16型为主,核酸多呈整合状态存在。上述结果表明,HPV在新疆某些地区内的人群中感染及传播的情况可能比较普遍。但要进一步阐明HPV与宫颈癌的病因学关系,尚需做更多的工作。
In this study, HPV-DNA-related sequences were examined in cervical and non-cancerous cervical tissues predominated by Uygur using nucleic acid hybridization. 33 cases of cervical cancer, cervical erosion in 1 case and normal cervical in 1 case. There are 25 cases of Uyghur in 33 cases of cervical cancer, the remaining 8 cases include Han, Mongolia, Hui and Kirgiz four nationalities. The result is HPV-DNA-related sequence detection rate of 80% in Uygur cases of cervical cancer, mainly HPV_16 type, nucleic acid mostly showed the status of integration. The above results show that HPV infection and transmission in some areas of Xinjiang may be more common. But to further clarify the etiology of HPV and cervical cancer relationship, still need to do more work.