论文部分内容阅读
目的：探讨胰腺癌的临床特征、治疗和预后。方法：对４７２例胰腺癌的临床资料进行回顾性研究，并对其中１８１例进行生存分析。结果：约半数为６０岁以上，且尚有增加趋势；年龄、性别和肿瘤部位与预后无明显相关，临床分期和淋巴结转移为影响预后的重要因素， ９０年代的预后较 ９０年代前明显好转（Ｐ＝０．００３），手术切除率和手术死亡率为 １２．５％和 １１．９％；术后 １年、３年和 ５年生存率分别为 ６８．８％、３７．５％和２５％，中位生存时间为４９个月，手术切除组生存率显著优于姑息手术组和化疗组。结论：胰腺癌的早期诊断仍未得到有效解决，手术切除仍是唯一有效提高长期生存率的治疗方法，但近十年来患者预后有所好转。
Objective: To investigate the clinical features, treatment and prognosis of pancreatic cancer. Methods: The clinical data of 472 cases of pancreatic cancer were retrospectively studied, and 181 of them were analyzed for survival. Results: About half of the patients were over 60 years of age, and there was an increasing trend; there was no significant correlation between age, gender and tumor location and prognosis. Clinical staging and lymph node metastasis were important factors affecting prognosis. The prognosis in the 1990s was significantly better than before 1990s ( P=0.003), surgical resection rate and operative mortality rate were 12.5% and 11.9%; postoperative 1-year, 3-year and 5-year survival rates were 68.8%, 37.5% and 25, respectively. The median survival time was 49 months. The survival rate of surgical resection group was significantly better than that of palliative surgery group and chemotherapy group. Conclusion: The early diagnosis of pancreatic cancer has not yet been effectively resolved. Surgical resection is still the only treatment that can effectively improve long-term survival. However, the prognosis of patients with pancreatic cancer has improved over the past decade.