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The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate (IP3) on intracellular Ca2+spiral patte evolution is studied numerically.The results indicate that when the IP3 concentration decreases from 0.27μM,a physiologically reasonable value,to different values,the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration.The instability of spiral patte can be understood in terms of excitability-change controlled by the IP3 concentration.On the other hand,when the IP3 concentration increases from 0.27μM,a homogeneous area with a high Ca2+ concentration emerges and competes with the spiral patte.A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium.The instability of spiral patte is ascribed to the change in stability of a stationary state with a high Ca2+ concentration.