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长链非编码RNA在调节细胞的生长、分化及其他生物学过程中具有重要作用,且与恶性肿瘤等常见疾病密切相关.人类长链非编码RNA PVT1的编码基因由于位于染色体8q24这一脆性位点且临近癌基因MYC而受到广泛关注.浆细胞瘤可变异位基因1(PVT1)在多种肿瘤中高表达,是潜在的癌基因;PVT1也能因染色体断裂重排而与其他基因形成新的融合基因影响恶性肿瘤的表型;PVT1还可与MYC基因相互作用,通过多种途径参与恶性肿瘤细胞的增殖、凋亡等调控.本文对PVT1在恶性肿瘤发生发展中的作用及其机制进行综述.
Long-chain non-coding RNA plays an important role in the regulation of cell growth, differentiation and other biological processes, and is closely related to common diseases such as malignant tumors.Coding genes of human long-chain non-coding RNA PVT1 are located in the fragile position of chromosome 8q24 Point and close to the oncogene MYC.PVT1 is highly expressed in many tumors and is a potential oncogene.PVT1 can also form new genes with other genes due to chromosome rearrangement Fusion gene affects the phenotype of malignant tumor, PVT1 also interacts with MYC gene and participates in the regulation of proliferation and apoptosis of malignant tumor cells via various pathways.In this paper, we review the role and mechanism of PVT1 in the development of malignant tumor .