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已有资料提示,肝癌的高发可能与婴儿时期的乙型肝炎病毒(HBV)持续感染有关。为此,我们于1981年11月至1983年11月对肝癌高发区0～3岁幼儿进行追踪2年的纵向观察。并于1983年对肝癌高发区和低发区0～9岁儿童进行了HBV感染标志的横向对比调查,以研究上述地区幼儿HBV感染的流行特征及与肝癌的关系。材料与方法一、观察对象(一) 选择1969～1983年肝癌年平均死亡率为52.0/10万的隆安县,对5～41个月龄的381名幼儿进行1年的追踪观察,其中222名幼儿进行2年的追踪观察。分别于初次、半年、1年和2年后进行调查和采血。
It has been suggested that the high incidence of liver cancer may be associated with persistent infection of hepatitis B virus (HBV) in infancy. To this end, we conducted a longitudinal 2-year follow-up of children aged 0-3 years with high incidence of HCC from November 1981 to November 1983. In 1983, a cross-sectional survey of HBV infection markers was performed in children aged 0-9 years in high incidence areas and low incidence areas of hepatocellular carcinoma to study the prevalence of childhood hepatitis B virus infection and the relationship with hepatocellular carcinoma in these areas. Materials and Methods 1.Objectives (1) To select 381 infants of 5 to 41 months of age who were followed up for one year in Longan County, with an average annual mortality rate of 52.0 / 100000 from 1969 to 1983, including 222 Children 2 years of follow-up observation. Investigate and collect blood after first, half, one and two years respectively.