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自1994年8月～1996年5月应用胸腔套管插管法闭式引流后胸腔内注入抗癌药物治疗癌性胸腔积液。随机分两组，一组应用榄香烯乳200～300mg，顺铂40mg，另一组应用顺铂60～80mg，每组17例进行对照分析。所有病例均经组织学或细胞学检查证实，均为单侧胸腔积液。Karnofsky评分50～80分（平均60分），确诊为癌性胸腔积液至开始治疗的中位时间1周。结果表明，加榄香烯乳组CR11例（64．7％），PRS例（29．4％），NC1例（5．9％），有效率94．1％；顺铂组CR5例（29．4％），PR10例（58．8％），NC2例（11．8％），有效率88．2％。两组总有效率相近，无显著差异。CR有显著差异（X2＝3．88，P＜0．05），加榄香烯乳组优于单顺铂组。副作用：榄香烯组包裹性液气胸3例，无其它毒副作用出现。顺铂组包裹性液气胸2例，消化道反应1级4例，2级2例，肾功能损害1级1例。
From August 1994 to May 1996, chest thoracic catheterization was used to inject anticancer drugs into the chest cavity to treat cancerous pleural effusion. Randomly divided into two groups, one group of elemene milk 200 ~ 300mg, cisplatin 40mg, the other group of cisplatin 60 ~ 80mg, 17 cases in each group for control analysis. All cases were confirmed by histological or cytological examinations and all were unilateral pleural effusions. The Karnofsky score was 50 to 80 points (mean 60 points). The median time from the diagnosis of cancerous pleural effusion to the start of treatment was 1 week. The results showed that there were 11 CR patients (64.7%), PRS patients (29.4%), NC1 patients (5.9%), 94.1% effective rate, and 5 CR patients in the cisplatin group. (4%) PR10 patients (58.8%), NC2 patients (11.8%), and effective rate 88.2%. The total effective rates of the two groups are similar, with no significant difference. There was a significant difference in CR (X2=3.88, P<0.05). Elemene milk group was superior to the monocisplatin group. Side effects: 3 cases of elemene group wrapped pneumothorax, no other toxic side effects. The cisplatin group included 2 cases of encapsulated liquid pneumothorax, 4 cases of digestive tract reaction in 1st grade, 2 cases of 2 cases, and 1 case of renal impairment.