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通过病例报告和临床研究结果,人们广泛认识到许多抗癫痫药与口服避孕药(OC)之间存在相互反应的潜在威胁。多数报告注意到作为肝微粒体药物代谢酶诱导剂的苯妥因、苯巴比妥、酰胺咪嗪和朴痫酮。广谱抗菌素也是妇女避孕失败的原因。英国医学安全委员会(CSM)通过黄卡呈报系统掌管着药物副反应(ADRs)的情况。本文采集了1968～1984年呈报的服用OC的孕妇同时接受抗癫
Through case reports and clinical studies, there is widespread awareness of the potential for many antiepileptic drugs and oral contraceptives (OCs) to interact with each other. Most reports have noted phenytoin, phenobarbital, amidipid and pristocin as inductors of liver microsomal drug-metabolizing enzymes. Broad-spectrum antibiotics are also the reason women contraceptive failure. The British Medical Safety Commission (CSM) rules drug side effects (ADRs) through the Yellow Card Reporting System. This article collected from 1968 to 1984 reported OC pregnant women taking anti-epilepsy