论文部分内容阅读
目的评价急性冠状动脉事件患者血管细胞间黏附分子1(ICAM-1)浓度及与脑缺血危险性的关系及临床意义。方法对沈阳军区总医院2009年1月至2010年03月入院急性冠脉综合征患者134例,双抗体夹心酶联免疫吸附法测定ICAM-1,并随访患者180 d内出现脑血管疾病的情况。结果轻度狭窄组、中度狭窄组、重度狭窄组3组间ICAM-1表达差异有统计学意义。中度狭窄组和重度狭窄组ICAM-1浓度显著增高,与对照组和轻度狭窄组比较差异有统计学意义。重度狭窄组中有36%出现TIA,与ICAM-1浓度随着血管狭窄的程度加重而增加的现象一致。而在冠状动脉左前降支发生狭窄超过50%的所有患者中,脑血管疾患的发生率也明显增加。结论 ICAM-1浓度和急性冠脉综合征患者冠脉狭窄程度及主要心血管不良事件率相关,监测ICAM-1浓度变化具有重要临床意义。
Objective To evaluate the relationship between the concentration of intercellular adhesion molecule-1 (ICAM-1) and the risk of cerebral ischemia in patients with acute coronary artery disease and its clinical significance. Methods 134 cases of acute coronary syndrome admitted to General Hospital of Shenyang Military Region from January 2009 to March 2010 were collected. ICAM-1 was detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and cerebrovascular disease was observed within 180 days . Results The expression of ICAM-1 in mild stenosis group, moderate stenosis group and severe stenosis group had statistical significance. The concentration of ICAM-1 in moderate and severe group was significantly higher than that in control group and mild group. TIA was present in 36% of the severe stenosis group, consistent with the increased ICAM-1 concentration as the degree of stenosis increased. In all patients with a stenosis of more than 50% in the left anterior descending coronary artery, the incidence of cerebrovascular disease was also significantly increased. Conclusions ICAM-1 concentration is related to the degree of coronary artery stenosis and major cardiovascular adverse events in patients with acute coronary syndrome. It is of great clinical significance to monitor the changes of ICAM-1 concentration.