论文部分内容阅读
目的 观察乙型肝炎病毒相关性肾炎 (HBV -GN)患者肾脏组织中HBsAg、HBcAg的表达情况。方法 以 6 3例HBV -GN患者为研究对象 ,另随机选择 2 0例非乙型肝炎病毒相关性肾炎 (NHBV -GN)患者、12例血清HBV标志阳性的其他肾病 (肾结核、肾结石、肾细胞癌、肾萎缩等 )患者作为对照组 ,用免疫组化方法检测肾穿刺活检组织HBsAg、HBcAg的表达。 结果 HBV -GN患者肾脏组织中均可检出HBsAg、HBcAg阳性颗粒 ,阳性率分别为 76 .2 % (4 8/ 6 3) ,4 2 .9% (2 7/ 6 3) ;2 0例NHBV -GN患者肾组织HBsAg、HBcAg均未检出 ,与HBV -GN患者相比有统计学差异 (P <0 .0 5 ) ;12例血清学HBV标志阳性的其它肾病患者肾组织HBsAg、HBcAg阳性率均为 75 % ,与HBV -GN患者相比无统计学差异 (P >0 .0 5 )。血清HBeAg阳性与血清HBeAg阴性的HBV -GN患者相比 ,肾脏组织中HBsAg、HBcAg表达情况经统计学比较 ,无显著性差异 (P >0 .0 5 )。结论 HBV在肾脏中定位及复制 ,不仅可引起肾脏损害 ,并与病毒的保存及乙型肝炎的传播可能有关。
Objective To observe the expression of HBsAg and HBcAg in the kidney of patients with hepatitis B virus associated nephritis (HBV-GN). Methods Totally 63 HBV-GN patients were enrolled in this study. Twenty patients with non-HBV-associated nephritis (NHBV-GN) were randomly selected. Twelve patients with other HBV-positive nephropathy (renal tuberculosis, kidney stones, Renal cell carcinoma, renal atrophy, etc.) as control group, immunohistochemical detection of renal biopsy tissue HBsAg, HBcAg expression. Results The positive rates of HBsAg and HBcAg in renal tissue of patients with HBV-GN were 76.2% (48/63) and 42.9% (27/63), respectively HBsAg and HBcAg were not detected in the kidney of patients with NHBV-GN, which were significantly different from those of patients with HBV-GN (P <0.05). The serum levels of HBsAg and HBcAg The positive rates were 75%, with no significant difference compared with HBV-GN patients (P> 0.05). Serum HBeAg positive HBeAg and HBcAg expression in kidney tissue compared with serum HBeAg negative HBV-GN patients showed no significant difference (P> 0.05). Conclusion HBV localization and replication in the kidney not only can cause kidney damage, but also with the preservation of the virus and the possible transmission of hepatitis B.