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目的探讨培氟沙星所致不良反应(ADR)的特点,为临床合理用药提供参考。方法对1989—2009年4月国内医药学期刊报道应用培氟沙星所致不良反应案例,并进行统计、分析。结果培氟沙星所致ADR临床主要表现为神经系统症状,占33.33%;过敏反应,占26.67%;消化系统症状,占16.67%;血液系统症状,占10.0%;泌尿系统症状,占6.67%。结论临床在使用培氟沙星时,应严格掌握其剂量、浓度及滴注速度,减少不良反应的发生。
Objective To investigate the characteristics of pefloxacin-induced adverse reactions (ADRs) and provide references for clinical rational drug use. Methods The cases of adverse reactions caused by pefloxacin in domestic medical journals from April 1989 to April 2009 were reported and analyzed statistically. Results Pefloxacin induced ADR clinical manifestations of neurological symptoms, accounting for 33.33%; allergic reactions, accounting for 26.67%; digestive system symptoms, accounting for 16.67%; hematological symptoms, accounting for 10.0%; urinary symptoms, accounting for 6.67% . Conclusion When using pefloxacin, the dose, concentration and infusion rate should be strictly controlled to reduce the occurrence of adverse reactions.