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乙基沛心达〔1’1-dicyclohexyl-2-(2’-N-ethylpiperidinyl)ethane maleate〕系北京大学研制的新药,具有抗心律失常作用。用本院动物中心提供的Wister大鼠检测了该药的致畸性。雌雄以1∶1同笼交配,受精鼠随机分组,每组20只。试验设120、60、15mg/kg三组,敌枯双15mg/kg为阳性对照组。乙基沛心达于孕期第7～16天灌胃给药,敌枯双于孕期第11天灌胃一次,溶剂对照组给予等体积二甲亚砜。结果表明,乙基沛心达120mg/kg组母鼠妊娠第6～20天增重39.8±32.0g,二甲亚砜对照组为70.2±23.5g,两组相比有非常显著性差别(P<0.01)。该组胎鼠尾长(12.7±0.7mm)缩短,与二甲亚砜对照组(13.2±0.6mm)相比有显著性差别(P<0.05)。未见胎鼠身长与体重明显变化。60～15mg/kg组母鼠体重、胎鼠身长、尾长和体重无明显异常。敌枯双阳性对照组胎鼠身长、尾长和体重与二甲亚砜溶剂对照组比较有显著性差别(P<0.05)。敌枯双阳性对照组胚胎吸收率明显升高(26.1%),
1’-dicyclohexyl-2- (2’-N-ethylpiperidinyl) ethane maleate is a new drug developed by Peking University and has anti-arrhythmic effects. The teratogenicity of this drug was tested in Wister rats provided by our hospital animal center. Male and female mating with 1: 1 cage, fertilized rats were randomly divided into groups of 20. Experimental set 120,60,15 mg / kg three groups, the enemy dry double 15mg / kg for the positive control group. Ethyl peixecent intragastric administration during the first 7-16 days of pregnancy, the enemy dry double on the 11th day of pregnancy gavage, solvent control group was given equal volume of dimethyl sulfoxide. The results showed that the weight gain of 39.8 ± 32.0g and 70.2 ± 23.5g on the 6th to 20th day in the Echocardiogram 120mg / kg group were significantly different between the two groups (P <0.01). Tail length (12.7 ± 0.7mm) shortened in this group was significantly lower than that in DMSO control group (13.2 ± 0.6mm) (P <0.05). No significant changes in fetal body length and weight. Body weight of 60 ~ 15mg / kg group, no abnormal fetal body length, tail length and weight. The body length, tail length and body weight of the fetal dry double positive control group compared with dimethyl sulfoxide solvent control group were significantly different (P <0.05). Embryo double positive control group embryonic absorption was significantly higher (26.1%),