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目的：探讨胃上部癌患者介入治疗后生存蛋白Survivin表达的变化。方法32例接受术前介入治疗的胃上部癌患者的新鲜标本，用免疫组织化学及Western-blot检测Survivin蛋白的表达。并与未接受术前介入治疗的患者进行比较。结果免疫组化所见Survivin染色阳性颗粒集中在细胞质，未介入治疗组强阳性率（72．9％）明显高于介入组的（50％）（P＜0．05）。通过Western-blots分析未介入治疗组条带的相对灰度值为（0．64±0．08），明显高于介入组的（0．37±0．03）（P＜0．05）。结论术前介入化疗能降低进展期胃癌术后Survivin表达，Survivin可以作为胃癌靶向治疗的候选靶点之一。“,”Objective To study the effects of preoperative i interventional therapy on survivin expression in patients with proximal gastric cancer.Methods Thritytwo 32 fresh samples obtained fromgastric cancer patients with preoperative interventional therapy were examined by immunohistochemistryand Western blot.Results Immunohistochemistry revealed that the positive stain particles of survivin concentrated in the cytoplasm.The positive rate of survivin expression in the operation group was higher thanthat of the intervention group(72.9% vs 50%,P <0.05).Western blot revealed that the greyscale valuein the operation group was greater than the of intervention group [(0.64 ±0.08)vs(0.37 ±0.03),P <0.05].Conclusion For patients with proximal gastric cancer,the expression of survivin can be downregulated by preoperative interventional therapy.Survivin is one of the candidate for targeted therapy for gastric neoplasm.