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龋病的发生一般认为是由于口腔菌群代谢产生的有机酸类所致,除此之外,还受遗传和社会等多因素调控。在该研究中,作者采用动物模型,观察了MHC和鼠龋易感性之间的关系。 材料和方法 该研究所用的鼠为:BALB/cJ鼠(H-2~(d/d),龋易感型),C3H/HeJ(H-2~(k/k)抗龋型)和BALB.K/Ola鼠(H-2~(k/k))。小鼠断奶后用2000型饲料,从出生后22天起经口注射50μl[10集落形成单位/毫升]致龋变的S.mutalls Jc-2血清型菌液,并保持适当的环境和温度。在小鼠出生后29天至60天期间用拭子培养法证实其牙齿表面的菌群。90天时,用乙醚将其
The occurrence of dental caries is generally considered to be due to the production of organic acids in oral flora, in addition to genetic and social factors such as regulation. In this study, the authors used animal models to examine the relationship between carotid susceptibility and MHC. Materials and Methods The mice used in this study were BALB / cJ mice (H-2 ~ (d / d), cario-susceptible), C3H / HeJ (H-2 ~ .K / Ola mice (H-2 ~ (k / k)). Mice were orally challenged with Model 2000, and cariogenic S. muruts Jc-2 serotypes were inoculated 50μl [10 colony-forming units / ml] 22 days after birth with appropriate environmental and temperature. The swab cultures were used to confirm the flora on the surface of the teeth between the 29th and 60th day after birth. 90 days, with ether