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喹诺酮类药物具有抗菌谱广、抗菌作用强、使用安全,易于制造等优良特性,在近十余年来得到了迅速的发展,由第一代的萘啶酸开始已发展成为一系列药物,目前第三代已有七个品种上市,在临床发挥着越来越重要的作用。近年不仅为改善已有品种的欠缺致力于发展新品种方面取得重大进展,同时在作用机制、耐药机制与构效关系等基础研究方面也取得了一定成就,为今后探索效能更好的新药提供了理论依据。尤其值得重视的是最近报道该类药物的研究已突破了抗菌的范畴,在抗病毒、抗肿瘤研究方面也有了良好的开端,展示了广阔的前景。
Quinolones have the advantages of wide antimicrobial spectrum, strong antibacterial effect, safe use and easy manufacture. They have been rapidly developed in the recent ten years and have been developed into a series of drugs starting from the first generation of nalidixic acid Three generations have seven varieties listed in the clinical play an increasingly important role. In recent years, not only has significant progress been made in improving existing varieties, but also in basic research on mechanisms of action, mechanism of drug resistance and the relationship between structure and effect. Some achievements have also been made in exploring more effective new drugs in the future The theoretical basis. In particular, it is worth noting that the recent reports of such drugs have broken the category of antimicrobials and have also made a good start in anti-viral and anti-tumor research and have shown broad prospects.