An efficient synthesis of novel benzo[b]pyrido[3',2':4,5]thieno[2,3-e][1,6]naphthy-ridine-

• 作 者: Dao-Lin Wang Yong-Yang Wang Xiao-Ce Shi Jian Ma
• 机 构: College of Chemistry and Chemical Engineering Liaoning Key Laboratory of Synthesis and Application o
• 出 处: Chinese Chemical Letters
• 发表日期: 2015年09期
• 关键词: benzo aldehydes Ziegler aromatic quinoline catalysis cyclization benzofuran cond

An efficient method for the synthesis of novel benzo[b]pyrido[3’,2’:4,5]thieno[2,3-e][l,6]naphthyridine-8-one derivatives has been developed using a Pictet-Spengler reaction between 4-(3-aminothieno[2,3-b]pyridin-2-yl)quinoline-2-ones,which could be obtained from the alkylation of4-bromomethylquinoline-2-ones with 3-cyanopyridine-2-thione followed by a Thorpe-Ziegler isomerization,and aromatic aldehydes under p-TsOH as catalysis in good yields.

An efficient method for the synthesis of novel benzo [b] pyrido [3 ’, 2’: 4,5] thieno [2,3-e] [1,6] naphthyridine-8-one derivatives has been developed using a Pictet- 2-ones with 3-aminothieno [2,3-b] pyridin-2-yl) quinoline-2-ones, could could be obtained from the alkylation of 4-bromomethylquinoline-2-ones with 3-cyanopyridine- followed by a Thorpe-Ziegler isomerization, and aromatic aldehydes under p-TsOH as catalysis in good yields.