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目的 :观察托马克治疗中晚期肺癌的近期疗效及毒副反应。方法 :74例肺癌病例中应用含有托马克及顺铂为主的联合化疗 ,共用 2～ 4个周期。结果 :近期疗效 :NSCLC :CR :3例 ,PR :2 8例 ,RR :4 8 4 %。SCLC :CR :1例 ,PR :5例 ,RR :60 %。毒副反应 :骨髓抑制 :WBC下降Ⅰ°、Ⅱ°、Ⅲ°分别是 1 8例、 2 8例、1 0例 ,占 75 7%。胃肠道反应Ⅰ°、Ⅱ°分别是 2 0例、 1 5例 ,占 4 7 3 %。肢端麻木 1 8例 ,占 2 4 3 % ,便秘 5例 ,占 6 8%。结论 :托马克治疗中晚期肺癌有较好的近期疗效
Objective: To observe the short-term curative effect and toxic and side effects of Totermalpine in the treatment of advanced lung cancer. Methods: Seventy-four cases of lung cancer were treated with combination chemotherapy with Tommec and cisplatin, sharing 2 to 4 cycles. Results: The short-term efficacy: NSCLC: CR: 3 cases, PR: 28 cases, RR: 48.4 %. SCLC: CR: 1 case, PR: 5 cases, RR: 60%. Side effects: Myelosuppression: WC decreased I°, II°, and III° were 18 cases, 28 cases, and 10 cases, accounting for 75.7%. Gastrointestinal responses I° and II° were 20 cases and 15 cases respectively, accounting for 47.7%. There were 18 cases of numbness in the extremities, accounting for 243%, and 5 cases of constipation, accounting for 68%. Conclusion: Tomac has better short-term efficacy in the treatment of advanced lung cancer