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[目的]探讨多药耐药相关蛋白和P-糖蛋白在膀胱癌表达的意义.[方法]应用兔疫组化法研究 48例膀胱移行细胞癌及6例正常膀胱粘膜标本多药耐药相关蛋白（MRP）、P-糖蛋白（P-gp）的表达。[结果]48例膀胱肿瘤中膀胱癌原发组和复发组P-gp的阳性表达率分别为46.9％和 68.7％,差异显著（P<0.05）,MRP的阳性表达率分别为 37.5％和 56.3％,差异显著（P<0.05）。[结论] P-gp和MRP的阳性表达与膀胱肿瘤的病理分级、分期呈正相关性,但无显著差异,MDR1与MRP之间无相关性。这两种蛋白的表达可能是膀胱内化疗失败的重要原因。
[Objective] To investigate the significance of multidrug resistance-related protein and P-glycoprotein expression in bladder cancer. [Methods] 48 cases of bladder transitional cell carcinoma and 6 cases of normal bladder mucosa were studied by immunohistochemistry Protein (MRP), P-glycoprotein (P-gp) expression. [Results] The positive rates of P-gp expression in primary and recurrent bladder cancer tissues were 46.9% and 68.7% respectively in 48 cases of bladder cancer (P <0.05), and the positive rates of MRP were 37.5% and 56.3 %, Significant difference (P <0.05). [Conclusion] The positive expression of P-gp and MRP is positively correlated with the pathological grade and stage of bladder neoplasm, but no significant difference between them. There is no correlation between MDR1 and MRP. The expression of these two proteins may be an important cause of intravesical chemotherapy failure.