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近年来,随着广谱抗生素和糖皮质激素的广泛应用,以及需要化疗的肿瘤患者和需要长期应用免疫抑制药的器官移植患者的增加,深部真菌已经成为医院感染较常见的病原体。在现有的抗真菌药物中,两性霉素B(AmB)是作用最强、抗菌谱最广的抗真菌药物之一。但因其不良反应严重,限制了其在
In recent years, with the widespread use of broad-spectrum antibiotics and glucocorticoids, and the increasing number of cancer patients requiring chemotherapy and organ transplantations requiring long-term use of immunosuppressive drugs, deep fungi have become the more common pathogens of nosocomial infections. Among the existing antifungal agents, amphotericin B (AmB) is one of the most potent and antimicrobial antifungal agents. However, due to serious adverse reactions, limiting its presence