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胰岛素抵抗(IR)与许多代谢异常相关,包括高胰岛素血症、中心性肥胖、血压升高以及血脂异常。大量以群体为基础的研究表明,人群中大约有25％的个体患有胰岛素抵抗。2型糖尿病患者胰岛素抵抗的发病率超过80％,胰岛素抵抗被认为是引发2型糖尿病的始动因素。1 胰岛素抵抗的定义 1.1胰岛素信号转导 胰岛素信号转导研究得比较深入的主要有两个途径:Ras复合途径和PI-3k途径。Ras复合途径主要实现胰
Insulin resistance (IR) is associated with many metabolic abnormalities, including hyperinsulinemia, central obesity, elevated blood pressure, and dyslipidemia. A large number of population-based studies indicate that approximately 25% of individuals in the population have insulin resistance. In patients with type 2 diabetes, the incidence of insulin resistance is more than 80%. Insulin resistance is considered as the initiating factor of type 2 diabetes. 1 Definition of Insulin Resistance 1.1 Insulin Signal Transduction Insulin signal transduction has two main pathways that have been studied in more depth: the Ras complex and the PI-3k pathway. Ras complex mainly to achieve the pancreas