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本发明具体涉及合成噁唑衍生物的方法,属于杂环化合物的合成领域。本发明所采用的技术方案为:以式(Ⅰ)所示的对甲苯磺酰甲基异腈衍生物为原料与式(Ⅱ)所示的酰氯反应制得α-酮亚胺氯化物式(Ⅲ);将中间体α-酮亚胺氯化物式(Ⅲ)和醛(Ⅳ)在质子性溶剂和碱存在条件下反应得到2-取代噁唑(Ⅴ)。与现有技术相比,本发明的方法所用原料价
The present invention particularly relates to a method for synthesizing an oxazole derivative, belonging to the field of synthesis of heterocyclic compounds. The technical scheme adopted in the invention is that the p-toluenesulfonyl methyl isonitrile derivative represented by the formula (I) is used as a raw material to react with an acid chloride represented by the formula (II) to obtain an α-ketimine chloride compound represented by the formula III); reacting the intermediate α-ketimine chloride of formula (III) with an aldehyde (IV) in the presence of a protic solvent and a base to give the 2-substituted oxazole (V). Compared with the prior art, the raw material price used in the method of the present invention