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由于目前尚无有效的抗HIV感染的化学药物和疫苗,从九十年代开始,人们开始日益重视探索HIV感染的基因治疗的新途径。HIV感染的基因治疗就是把具有治疗作用的基因转移到合适的靶细胞中,使其在表达为RNA或蛋白质后干扰HIV基因表达及调控,以达到防治HIV感染的目的。HIV的分子生物学研究的深人和体细胞基因治疗技术的发展为HIV感染的基因治疗提供了基础。目前采用的策略主要有三大类:抗病毒的基因治疗;细胞毒性基因治疗和兔疫调节基因治疗。其中已有一些临床实验方案付诸实施。
Since there is currently no effective anti-HIV chemical and vaccine, there has been an increasing emphasis from the nineties on exploring new ways of gene therapy for HIV infection. The gene therapy of HIV infection is to transfer the gene with therapeutic effect into appropriate target cells so as to interfere with the gene expression and regulation of HIV after expressed as RNA or protein so as to achieve the purpose of preventing and treating HIV infection. The development of deep and somatic gene therapy techniques for HIV molecular biology provides the basis for gene therapy for HIV infection. Currently there are three main strategies used: anti-viral gene therapy; cytotoxic gene therapy and vaccination regulation of gene therapy. There are already some clinical trial programs put into practice.