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This study was designed to determine the levels of early endothelial progenitor cells(EPCs),apelin,vascu-lar endothelial growth factor(VEGF) and stromal cell-derived growth factor-1(SDF-1) after acute myocardial infarction(AMI),and to investigate the relationships between these cytokines and early EPCs.Early EPCs,de-fined as CD133+,KDR+,and CD34+ cells,were quantified by flow cytometry.The levels of early EPCs and those cytokines in AMI patients were significantly different from those with coronary artery disease or controls(P < 0.05).Plasma apelin levels were inversely correlated with Gensini score and early EPCs(both P < 0.01).Early EPCs,VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h.The trend in the change of early EPCs was proportionally correlated with that of VEGF(P < 0.05).AMI patients exhibited in-creased early EPCs with remarkably decreased apelin levels and enhanced VEGF levels.
This study was designed to determine the levels of early endothelial progenitor cells (EPCs), apelin, vascu-lar endothelial growth factor (VEGF) and stromal cell-derived growth factor-1 (SDF-1) after acute myocardial infarction (AMI) and to investigate the relationships between these cytokines and early EPCs. Early EPCs, de-fined as CD133 +, KDR +, and CD34 + cells, were quantified by flow cytometry. The levels of early EPCs and those cytokines in AMI patients were significantly different from those with Coronary artery disease or controls (P <0.05) .Plasma apelin levels were inversely correlated with Gensini score and early EPCs (both P <0.01). Allar EPCs, VEGF and SDF-1 showed different patterns of changes in AMI patients during the first 24 h. The trend in the change of early EPCs was proportionally correlated with that of VEGF (P <0.05). AMI patients showed in EPC-marked early EPCs with remarkably decreased apelin levels and enhanced VEGF levels.