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HIV-1能引起AIDS,但其原发感染时常引起急性、自限性伴多种临床表现的病毒血症。先期研究已从原发感染病人的血浆、外周血淋巴细胞及脑脊液中分离培养出HIV-1,在血浆中检测到一过性的HIV-1P24抗原。为探明HIV-1感染初期病毒复制、宿主免疫应答及其临床表现的关系,本文作者对三位症状性原发感染HIV-1病人及其中一个性伴侣的外周血和血浆中HIV-1进行定量分子学、生物学分析。具体方法如
HIV-1 can cause AIDS, but its primary infection often causes acute, self-limiting viremia with a variety of clinical manifestations. Previous studies have isolated HIV-1 from the plasma, peripheral blood lymphocytes and cerebrospinal fluid of primary infected patients and detected transiently HIV-1 P24 antigens in the plasma. To determine the relationship between viral replication, host immune response and clinical manifestations at the initial HIV-1 infection, we performed HIV-1 in peripheral blood and plasma from three symptomatic primary HIV-1 patients and one of their sexual partners Quantitative molecular biology analysis. Specific methods such as