Nucleus-targeted Dmpl transgene fails to rescue denta defects in Dmpl null mice

• 作 者: Shu-Xian Lin Qi Zhang Hua Zhan
• 机 构: DepartmentofBiomedicalSciences,TheStateKeyLaboratoryBreedingBaseofBasicScienceofStomatology（Hubei-MO
• 出 处: 国际口腔科学杂志：英文版
• 发表日期: 2014年3期
• 关键词: 转基因小鼠 细胞核定位 缺陷 牙本质基质蛋白1 信号传导途径 成牙本质细胞 基因突变 转录因子 autosomal recessive hypophosphat
• 基金项目: supported by NIH grants DE018486 and R56 DE022789 to Jian-Quan Feng, DE023365 to Yong-Bo Lu and a scholarship from the Chinese State Scholarship Fund to Shu-Xian Lin (2010627108)

Dentin matrix protein 1(DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protei