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目的观察小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎的临床效果。方法选取遂平县第二人民医院儿科2014年9月—2015年9月收治的小儿重症肺炎118例,按照随机数字表法分为对照组与研究组,各59例。对照组给予常规治疗,研究组在对照组基础上应用小剂量多巴胺联合多巴酚丁胺进行治疗。比较两组患儿治疗后的临床疗效、临床症状缓解时间及不良反应发生情况。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组患儿心率改善时间、肺部啰音消失时间、呼吸改善时间及三凹征消失时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用小剂量多巴胺联合多巴酚丁胺治疗小儿重症肺炎疗效显著,能够缩短患儿的临床症状缓解时间,且不增加不良反应。
Objective To observe the clinical efficacy of low-dose dopamine combined with dobutamine in children with severe pneumonia. Methods A total of 118 children with severe pneumonia admitted to the Second People’s Hospital of Suiping County from September 2014 to September 2015 were selected and divided into control group and study group (n = 59) according to random number table. The control group was given conventional treatment. The study group was treated with low-dose dopamine combined with dobutamine in the control group. The clinical curative effect, clinical symptom remission time and adverse reaction were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group (P <0.05). The improvement rate of heart rate, the time of pulmonary rales disappearance, the time of respiration improvement and the disappearance of the three depressions were all shorter in the study group than in the control group Control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion Small dose of dopamine combined with dobutamine for the treatment of severe pneumonia in children has significant curative effect, which can shorten the time of clinical symptom relief in children and does not increase the adverse reaction.