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本实验观察到肌肉注射氧化苦参碱具有明显延长小鼠异体游离移植心肌存活期的作用,并随剂量加大其作用增强。检查药物对移植和非移植小鼠的脾脏淋巴细胞转化和免疫球蛋白分泌细胞的影响。实验发现,移植术后10天小鼠体外脾脏细胞自发增殖增强,对刀豆蛋白 A(ConA)刺激的转化反应则明显减弱。氧化苦参碱显著抑制正常小鼠的脾细胞的自发增殖及对 ConA 或脂多糖(LPS)刺激的转化反应,而对手术已使之显著降低的脾细胞对 ConA 刺激的转化反应无影响。这种选择性抑制作用可能利于避免用其他常规非特异免疫抑制剂所带来的危害。
In this experiment, it was observed that intramuscular injection of oxymatrine significantly prolonged the survival of mice with allogeneic free-graft myocardial survival, and its effect increased with increasing dose. Examination of the effect of the drug on spleen lymphocyte transformation and immunoglobulin-secreting cells in transplanted and non-transplanted mice. It was found that the spontaneous proliferation of splenocytes in vitro was enhanced at 10 days after transplantation, and the conversion reaction to concanavalin A (ConA) stimulation was significantly reduced. Oxymatrine significantly inhibited the spontaneous proliferation of spleen cells from normal mice and the conversion response to ConA or lipopolysaccharide (LPS) stimulation, whereas splenocytes that had been significantly reduced by surgery had no effect on ConA-stimulated conversion. This selective inhibition may be beneficial to avoid the harm caused by other conventional non-specific immunosuppressive agents.