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目的测定手足口病(HFMD)患儿血清神经元特异性烯醇化酶(NSE)水平,为了解本病中枢神经系统损害提供科学依据。方法 2012年4～5月住院的手足口病患儿54例,按照入院时有无神经系统受累表现分为神经系统受累组和神经系统未受累组,检测两组患儿血中的NSE水平,并观察神经系统未受累组患儿是否出现神经系统受累表现。结果 33例神经系统受累组手足口病患儿血NSE水平为(55.68±33.36)ng/ml,21例神经系统未受累组为(38.41±13.61)ng/ml,两组比较差异有统计学意义(P<0.05);21例神经系统未受累组有7例入院后出现神经系统受累表现,入院后出现神经系统受累组NSE(53.73±10.52)ng/ml,一直无神经系统受累表现组(30.75±5.79)ng/ml,两者差异有统计学意义(P<0.01)。结论手足口病患儿血NSE水平升高,提示手足口病患儿中枢神经系统受累,且NSE增高早于神经受累临床表现出现,对早期诊断有指导意义。
Objective To determine the level of serum neuron specific enolase (NSE) in children with hand-foot-mouth disease (HFMD) and provide a scientific basis for understanding the CNS damage in this disease. Methods 54 children with hand-foot-mouth disease admitted from April to May in 2012 were divided into nervous system involvement group and nervous system non-involvement group according to the presence or absence of nervous system involvement on admission. NSE levels in the two groups were detected, And to observe the nervous system is not involved in the presence or absence of nervous system involvement in children with performance. Results The level of NSE in the 33 children with HFMD was (55.68 ± 33.36) ng / ml and that in 21 patients without neurological involvement was (38.41 ± 13.61) ng / ml, with significant difference between the two groups (P0.05) .Among the 21 patients without neurological involvement, 7 patients had neurological involvement after admission. The neurological involvement group showed NSE (53.73 ± 10.52) ng / ml after admission, and there was no neurological involvement group (30.75 ± 5.79) ng / ml, the difference was statistically significant (P <0.01). Conclusions The level of NSE in children with HFMD is elevated, which indicates that CNS involvement in children with HFMD and the clinical manifestations of NSE increased earlier than that of neurological involvement, which may be helpful for early diagnosis.