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目的:分析非酒精性脂肪性肝病(NAFLD)的临床及生化特征,以探讨NAFLD与代谢综合征(MS)的相关性。方法:对2248例在青岛大学医学院附属青岛市市立医院体检中心进行健康体检的人群,进行身高、体重、腰围、血压、血脂、空腹血糖、血尿酸等指标检测,空腹行腹部B超检查。结果:NAFLD组中肥胖、中心性肥胖、高血压、血脂异常、糖代谢异常、高尿酸血症的检出率明显高于对照组(P<0.01),Logistic回归分析显示腰围、甘油三酯、空腹血糖、体重指数、性别与NAFLD密切相关,NAFLD组中MS伴发率明显高于对照组(48.62%vs19.13%,P<0.01)。结论:NFALD与MS密切相关,NAFLD患者具有MS各组分集聚的特征,应重视NAFLD对心脑血管疾病的影响。
Objective: To analyze the clinical and biochemical characteristics of non-alcoholic fatty liver disease (NAFLD) to explore the correlation between NAFLD and metabolic syndrome (MS). Methods: Totally 2248 healthy subjects were examined in physical examination center of Qingdao Municipal Hospital of Medical College of Qingdao University. The height, weight, waist circumference, blood pressure, blood fat, fasting blood glucose, blood uric acid and other indexes were detected. Results: The prevalence of obesity, central obesity, hypertension, dyslipidemia, abnormal glucose metabolism and hyperuricemia in NAFLD group was significantly higher than that in control group (P <0.01). Logistic regression analysis showed that waist circumference, triglyceride, Fasting blood glucose, body mass index, sex and NAFLD are closely related. The incidence of MS in NAFLD group was significantly higher than that in control group (48.62% vs 19.13%, P <0.01). CONCLUSION: NFALD is closely related to MS. NAFLD patients have the characteristics of clustering of MS components. The impact of NAFLD on cardiovascular and cerebrovascular diseases should be emphasized.