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目的分析高龄孕妇的胎儿染色体核型检查结果,探讨高龄妊娠胎儿染色体异常的风险。方法对1448例高龄孕妇行羊膜腔穿刺,抽取羊水细胞进行培养,制备染色体并对染色体核型进行分析。结果 1448例高龄孕妇,检出异常核型53例,其中常染色体数目异常39例,性染色体异常5例,其他结构异常9例。结论高龄孕妇进行羊水细胞产前诊断是必要的。
Objective To analyze the results of fetal chromosome karyotype examination in elderly pregnant women and explore the risk of fetal chromosomal abnormalities in elderly pregnant women. Methods 1448 pregnant women underwent amniocentesis and amniotic fluid cells were cultured for chromosome preparation and chromosome karyotype analysis. Results Among 1448 pregnant women, 53 cases of abnormal karyotype were detected, including 39 cases with abnormal autosomal chromosome number, 5 cases with sex chromosome abnormality and 9 cases with other structural abnormalities. Conclusion Prenatal diagnosis of amniotic fluid cells in pregnant women is necessary.