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目前研究急性呼吸窘迫综合征(ARDS)常用家兔油酸等动物模型,但与临床差距较大。犬、兔等一次静注内毒素所致休克合并ARDS改变者又较少、较轻。我们根据临床急性戚染合并ARDS多发生在发病18小时以后,尿内儿茶酚胺明显高于不合并者,以及肺的病理改变与家兔皮肤内毒素施瓦茨曼反应有相似之处的启示,将局部施瓦茨曼反应改在肺,并加用肾上腺素,建成了更接近人类的家兔内毒素-肾上腺素“ARDS”模型。 实验Ⅰ组15只,将大肠杠菌内毒素3毫克/公斤溶于1毫升/公斤生理盐水中,于2小时内分四次注入气管。24小时后家兔血压正常、呼吸基本平稳、动脉氧分压(PaO_2)均值为90.4毫米汞柱。静注内毒素1毫克/
The current study of acute respiratory distress syndrome (ARDS) commonly used rabbit animal model of oleic acid, but with large clinical gaps. Dogs, rabbits and other intravenous endotoxin caused by shock combined with ARDS and less, less. According to our clinical findings, ARDS combined with ARDS occurred in 18 hours after onset, urinary catecholamine was significantly higher than non-mergers, and lung pathological changes and rabbit skin endotoxin Schwartz reaction similar to the revelation, The local Schwarzman response was changed to the lungs and adduct with epinephrine to create a closer-to-human rabbit endotoxin-adrenergic “ARDS” model. In group I, 15 rats were treated with 3 mg / kg of endotoxin in E.coli and dissolved in 1 ml / kg of normal saline. The animals were injected into the trachea four times in two hours. Twenty-four hours later, the rabbits had normal blood pressure and stable breathing. The mean value of PaO_2 was 90.4 mmHg. Intravenous endotoxin 1 mg /