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自1987年以来,澳大利亚应用Biken(日本大阪微生物疾病研究基金会)的鼠脑福尔马林灭活冻干疫苗(Nakayama-NIH株)证明是有效的。以前对该疫苗的超敏反应报道很少。但最近,接种乙型脑炎(JE)疫苗后出现严重不良反应的病例明显增多。这种不良反应很可能与疫苗有关。病例1 18岁女性,接种第1针疫苗后无异常。接种第2针(批号EJNo17)后3天,出现荨麻疹,接着几小时内出现呼吸困难,血压过低。住院注射肾上腺素和皮质类固醇,几天后恢复。
Since 1987, the mouse brain formalin-in-lyophilized freeze-dried vaccine (Nakayama-NIH strain) using Biken (Osaka, Japan Microbial Disease Research Foundation) has been shown to be effective. Hypersensitivity reactions to the vaccine were rarely reported before. Recently, however, there have been marked increases in serious adverse reactions after vaccination with Japanese encephalitis (JE) vaccine. This adverse reaction is likely to be associated with the vaccine. Case 1 18-year-old female, vaccinated with the first one after the vaccine was normal. Urticaria occurred 3 days after inoculation of the second needle (lot EJNo17), followed by dyspnea within a few hours and hypotension. Hospitalized epinephrine and corticosteroids, recovered after a few days.