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本实验以40只家兔分包公藤组、匹罗卡品组及异丙基肾上腺素组三组,除组间比较外,每兔随机各取一眼作实验眼,另一眼作为自身对照眼进行分析。结果发现包甲素与匹罗卡品不论从药理效应或对环核苷酸的含量影响上显然具有类同的作用。反映了其拟付交感作用的一致性,而与拟交感药物(异丙肾)相比则其作用截然不同,在本实验中观察到包甲素和匹罗卡品都能使cGMP上升,而包甲素比匹罗卡品的作用更强,(P<0.01)。异丙肾使cAMP↑cGMP↓,而包甲素有使cAMP↓cGMP↑的趋向与国外文献对交感与付交感药物列环核苷酸(cAMP、cGMP)的影响的报导相一致,这对植物神经调节、细胞功能调节以至祖国医学中阴阳学说的近代研究又提供一实验资料。在缩瞳作用方面,包甲素与匹罗卡品二者均具显著的缩瞳作用(P值分别<0.001,<0.01)。而在降低眼压方面二者均不显著。
In this experiment, 40 rabbits were subconjugated with the group of tripterygium, the pilocarpine group and the isoproterenol group. Except for the comparison among groups, each rabbits were randomly selected one experimental eye and the other as their own control eye analysis. The results showed that the inclusion of palmatine and pilocarone both from the pharmacological effects or on the content of cyclic nucleotides obviously have the same effect. Reflects the consistency of its intended sympathetic effect, whereas its effect is distinctly different from that of the sympathomimetic drug (isoproterenol). In this experiment, it was observed that both ctenophavin-1 and pilocarpine increased cGMP, whereas The effect of PLA was stronger than that of pilocarpine (P <0.01). Isoproterenol causes cAMP ↑ cGMP ↓, whereas the trend of cAMP ↓ cGMP ↑ is consistent with that of foreign literature on the sympathetic and sympathetic effects of cAMP (cAMP, cGMP) Modern regulation of neuromodulation, regulation of cell functions and even the theory of yin and yang in the motherland medicine provide an experimental data. In the role of miosis, both paclitaxel and pilocarpine both have significant miotic effect (P values were <0.001, <0.01). Both were insignificant in reducing IOP.