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AIM:To evaluate the relationship between gallbladder (GB) motor function and H pylori infection in the stomach.METHODS:All cases (86) underwent the 14C urea breath test (UBT).14C-UBT was found as positive in 58 and negative in 28 dyspeptic patients.14C- UBT was accepted as a gold standard test.Clo test and histopathologic examination were compared with the results of 14C-UBT in cases who tolerated upper gastrointestinal endoscopy procedure.Cholescintigraphy with 99mTc-mebrofenin was used to determine the parameters of GB motor function (GB filling and emptying time,half of the emptying time,ejection fraction at 30th and 60th min) in all patients.RESULTS:We found the sensitivity and specificity as 88% and 86% for CIo test and as 89% and 80% for histologic evaluation,respectively.The parameters of GB function were not significantly different in H pylori positive and negative patients.The GB emptying was normal in both groups.Minimum GB filling time was 30 min in 34 of 86 cases (39.5%),filling was not observed in 2 cases.The GB ultrasonography (USG) results were normal for all cases and bile composition abnormality was not determined.CONCLUSION:Our study showed that 14C-UBT is highly reliable method to detect the presence of H pylori.The presence of H pylori infection does not directly affect the GB function.