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目的：在急性心肌梗死行紧急经皮冠状动脉腔内成形术（ＰＴＣＡ）后观察中性粒细胞（ＰＭＮ）的活性变化过程。方法：２４例急性心肌梗死行紧急ＰＴＣＡ的病例，根据血管阻塞的程度及有无侧支循环的形成分为缺血不完全组（ｎ＝１０）和缺血完全组（ｎ＝１４），测定ＰＭＮ产生超氧阴离子自由基的活性作用。结果：缺血完全组在ＰＴＣＡ后较缺血不完全组ＰＭＮ的活性明显增强，同时血浆丙二醛（ＭＤＡ）含量也增高。结论：在急性心肌梗死行紧急ＰＴＣＡ后可能存在着由ＰＭＮ介导的心肌缺血再灌注损伤，而且ＰＭＮ的活性与血管阻塞程度有关。
Objective: To observe the change of neutrophil (PMN) activity after acute percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction. Methods: Twenty-four patients with acute PTCA undergoing acute myocardial infarction (AMI) were divided into two groups according to the degree of vascular occlusion and the formation of collateral circulation: incomplete ischemia group (n = 10) and complete ischemia group (n = 14) PMN produces superoxide anion radical activity. Results: The activity of PMN in ischemic complete group was significantly higher than that in incomplete ischemic group after PTCA, meanwhile the plasma malondialdehyde (MDA) content also increased. CONCLUSION: PMN-mediated myocardial ischemia-reperfusion injury may occur after acute PTCA in acute myocardial infarction, and the activity of PMN is related to the degree of vascular occlusion.