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本文主要阐述胆汁酸的致癌机制。胆汁酸的致癌作用要追溯到1932年Cook等的发现:脱氧胆酸可转变为有致癌作用的20-甲基胆蒽(20-methylcholanthrene);脱氧胆酸注入皮下时会发生癌肿。胆汁酸可能通过酶作用转变为致癌物质,引起人们广泛的注意。胆汁酸(C_(24)类固醇)是胆固醇的代谢产物。初级胆汁酸包括胆酸及鹅脱氧胆酸均在肝内合成,从胆汁分泌,大部分再由肠道吸收,少量从粪便排出,经每天许多
This article focuses on the carcinogenic mechanism of bile acids. The carcinogenic effect of bile acids dates back to 1932, when Cook et al. Found that deoxycholic acid can be converted to 20-methylcholanthrene, an oncogenic agent; carcinogenesis occurs when deoxycholic acid is injected subcutaneously. Bile acids may be converted into carcinogens by enzymes, causing widespread attention. Bile acids (C 24 steroids) are the metabolites of cholesterol. Primary bile acids, including cholic acid and chenodeoxycholic acid are synthesized in the liver, secreted from the bile, most of them absorbed by the intestine, a small amount of excretion from the faeces, many daily