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HIV-1(human immunodeficiency virus type 1)病毒感染因子Vif(viral infectivity factor)是高度保守的碱性磷酸化蛋白质,是HIV-1的辅助调节蛋白之一。Vif蛋白的主要功能是能够介导宿主细胞体内载脂蛋白BmRNA编辑酶催化多肽样蛋白3G(apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G,APOBEC3G)的降解,从而增强病毒的感染性。此外,它还具有调节病毒的逆转录和复制晚期以及诱导细胞G2期停滞等功能。目前,许多实验室已经针对Vif蛋白进行抑制剂的设计。本文简要叙述了Vif蛋白的结构与功能,并主要对其抑制剂的最新进展进行了综述。
Human immunodeficiency virus type 1 Vif (viral infectivity factor) is a highly conserved basic phosphorylated protein that is one of the co-regulatory proteins of HIV-1. The main function of Vif protein is to mediate the degradation of apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G (APOBEC3G) in the host cell so as to enhance the virus’s infectivity. In addition, it has the function of regulating the reverse transcription and replication of the virus and inducing cell G2 arrest. Currently, many laboratories have designed inhibitors of Vif protein. This article briefly describes the structure and function of Vif protein, and reviews its recent advances in inhibitors.