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目的:确定L-型钙通道阻滞剂对吗啡奖赏记忆再巩固的影响。方法:采用大鼠条件性位置偏爱模型,条件性线索暴露后,单次系统给予硝苯地平和维拉帕米,观察其对吗啡奖赏记忆条件位置偏爱分值的影响,同时检测对自发活动的影响。结果:维拉帕米组与对照组相比,条件性位置偏爱分值明显降低,统计学差异具有显著性(P<0.05),其自发活动统计学差异无显著性(P>0.05)。硝苯地平组与其对照组相比,条件性位置偏爱分值统计学差异无显著性(P>0.05),硝苯地平组自发活动降低(P<0.05),差异有显著性。结论:维拉帕米可干扰药物奖赏记忆再巩固的过程,且对大鼠自发活动没有影响,具有潜在的戒毒防复吸的临床应用前景,而硝苯地平对奖赏记忆作用不明显,且加大剂量明显抑制大鼠自发活动,其戒毒防复吸作用受到限制。
Objective: To determine the effect of L-type calcium channel blockers on the re-consolidation of morphine reward memory. Methods: The conditioned place preference model was used in rats. After exposure to conditional clues, nifedipine and verapamil were given in a single system. The effects of placebo on morphine reward memory condition were observed. Meanwhile, influences. Results: Compared with the control group, the value of conditional preference score in verapamil group was significantly lower (P <0.05), and there was no significant difference in spontaneous activity between the two groups (P> 0.05). Nifedipine group compared with the control group, the conditional position preference score was no significant statistical difference (P> 0.05), nifedipine group spontaneous activity decreased (P <0.05), the difference was significant. Conclusion: Verapamil interferes with the process of drug re-memory re-consolidation, and has no effect on spontaneous activity in rats. It has potential clinical application prospect of drug rehabilitation and anti-relapse. Nifedipine has no obvious effect on reward memory. High-dose significantly inhibited spontaneous activity in rats, its anti-retrovirulence is limited.