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目的探讨凋亡抑制蛋白XIAP在喉癌组织中的表达及其临床意义。方法从107例喉癌患者中,随机抽取42例喉癌及癌旁组织切片作对照,应用免疫组织化学二步法测定其XIAP蛋白的表达情况。结果在42例喉癌及癌旁组织中,XIAP表达两组间比较差异有统计学意义(P<0.01);在临床病理分级两组间比较差异有统计学意义(P<0.05);在性别、年龄和有无颈部淋巴结转移各两组间比较,差异无统计学意义(P>0.05)。结论凋亡抑制蛋白XIAP在喉癌的发生发展中起重要作用,但和性别、年龄和有无颈部淋巴结转移差异无相关性。
Objective To investigate the expression of XIAP in laryngeal carcinoma and its clinical significance. Methods Totally 107 cases of laryngeal cancer patients were randomly selected from 42 cases of laryngeal cancer and para-carcinoma tissue sections as controls. The expression of XIAP protein was detected by immunohistochemical two-step method. Results There were significant differences in the expression of XIAP between the two groups (P <0.01) in 42 cases of laryngeal carcinoma and paracancerous tissues. There was significant difference between the two groups in clinical pathological grade (P <0.05) , Age and neck lymph node metastasis between the two groups, the difference was not statistically significant (P> 0.05). Conclusion The apoptosis-inhibiting protein XIAP plays an important role in the development of laryngeal carcinoma, but it has no correlation with the gender, age and the presence or absence of cervical lymph node metastasis.