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大肠癌是人类最常见的恶性肿瘤之一,其发病率呈逐年上升趋势。尽管大肠癌的治疗手段有较大的改进,但其5年生存率仍然不高。大肠癌的侵袭转移是患者预后差和死亡的主要原因,其过程除受传统的黏附分子、蛋白水解酶的调控之外,趋化因子及其受体、血管内皮生长因子、缺氧、microRNAs等多种因素的参与也越来越受重视。因此,研究这些因素在大肠癌的侵袭转移中的作用,对其预后的估计和指导临床治疗有着重要意义。
Colorectal cancer is one of the most common malignant tumors in human beings, and its incidence has been increasing year by year. Although the treatment of colorectal cancer has been greatly improved, but its 5-year survival rate is still not high. Invasion and metastasis of colorectal cancer is the main reason for poor prognosis and death in patients. In addition to the traditional regulation of adhesion molecules and proteolytic enzymes, chemokines and their receptors, vascular endothelial growth factor, hypoxia, microRNAs, etc. The participation of many kinds of factors is also paid more and more attention. Therefore, the study of these factors in the invasion and metastasis of colorectal cancer plays an important role in the estimation of prognosis and clinical treatment.