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目的观察异常子宫出血患者单纯增型与正常增生期子宫内膜雌激素受体(Estrogen receptor,ER)、孕激素受体(Progestron receptor,PR)表达有无差异。方法门诊宫腔镜下观察需行诊刮的异常子宫出血患者的子宫内膜组织,石蜡包埋制成病理切片,HE染色按内膜的病理类型分为单纯增生型和正常增生期子宫内膜两组,用免疫组织化学方法测定ER、PR含量,采用LeicaQ500IW图像分析仪进行测定,应用光密度值进行比较。结果异常子宫出血患者单纯增生型和正常增生期子宫内膜的ER、PR分布不同,单纯增生病变部位ER、PR含量高于正子宫内膜组织部位。结论异常子宫出血患者单纯增生型和正常增殖期子宫内膜的ER、PR含量不同;ER、PR在子宫内膜增殖中起了非常重要的作用。
Objective To observe whether estrogen receptor (ER) and progestron receptor (PR) expression of endometrium in patients with abnormal uterine bleeding were increased or not. Methods Outpatient hysteroscopic observation of patients with endometriosis requiring curettage of abnormal uterine bleeding, paraffin-embedded into the pathological section, HE staining according to the pathological type of endometrium is divided into simple hyperplastic and normal proliferative endometrium Two groups, immunohistochemical method for determination of ER, PR content, using LeicaQ500IW image analyzer was measured, the application of optical density values were compared. Results The distribution of ER and PR in endometrial hyperplasia and proliferative endometrium in patients with abnormal uterine bleeding were different. The content of ER and PR in the hyperplastic lesion was higher than that in the endometrial tissue. Conclusions Patients with abnormal uterine bleeding have different levels of ER and PR in proliferative and proliferative endometrium. ER and PR play a very important role in the proliferation of endometrium.