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目的观察NP方案新辅助化疗联合外照射治疗溃疡型食管癌能否提高放疗疗效以及减少患者在放疗中食管穿孔等并发症的发生。方法1998年6月-2002年6月用新辅助化疗配合外照射治疗溃疡型食管癌研究。新辅助化疗+外照射治疗112例(综合组),单纯外照射治疗112例(单放组)。结果综合组和单放组病例出现穿孔趋势的分别为8%、48%,胸痛分别为20%、82%。近期疗效2个组有显著差异(P<0.01)。结论研究显示用NP方案新辅助化疗配合外照射治疗溃疡型食管癌能降低食管溃疡穿孔的发生率,提高近期疗效及生存率。
Objective To observe whether NP regimen neoadjuvant chemotherapy combined with external beam irradiation for the treatment of ulcerated esophageal cancer can improve the radiotherapy efficacy and reduce the incidence of esophageal perforation and other complications in patients undergoing radiotherapy. Methods June 1998-June 2002 with neoadjuvant chemotherapy combined with external beam irradiation for the treatment of ulcerated esophageal cancer. Neoadjuvant chemotherapy + external beam irradiation treatment of 112 cases (comprehensive group), simple external beam irradiation treatment of 112 cases (radiotherapy group). Results The perforation tendency of the combination group and the single radiotherapy group were 8% and 48% respectively, and chest pain was 20% and 82% respectively. The recent efficacy of two groups were significantly different (P <0.01). Conclusions The study shows that NP regimen with neoadjuvant chemotherapy combined with external irradiation for the treatment of ulcerated esophageal cancer can reduce the incidence of esophageal ulcer perforation and improve the short-term efficacy and survival rate.